| 摘要 |
The invention relates to expression vectors of the telomerase reverse transcriptase, especially non integrative vectors such as those derived from adeno-associated viruses (AAV), preferably derived from AAV9, as well as to its use for the amelioration of markers of ageing such as insulin insensitivity, osteoporosis, loss of neuromuscular coordination, loss of memory, and the longevity itself. It is based on the fact that treatment of 1-yr and 2-yr old mice with an adeno associated virus (AAV) of wide tropism expressing telomerase had remarkable beneficial effects on health and fitness, including the mentioned markers of ageing and the lifespan itself. Importantly, telomerase-treated mice did not develop more cancer than their control littermates, So, these results demonstrate that telomerase-based therapies can be used to improve healthy ageing and extend longevity in an adult/old mammalian organism without increasing the risk of cancer. |
