MICRORNA AND USES IN BROWN FAT DIFFERENTIATION

摘要

This invention reveals a novel miRNA and a novel miRNA-regulated signaling network which controls brown adipogenesis and thermogenic programs, thereby providing a powerful approach for the treatment of obesity and related metabolic diseases. In this regard, the present invention is also directed towards methods of treatment of obesity and excess weight (overweight) and metabolic disorders caused by or aggravated by a subject being overweight or obese.

主权项

1. A method of regulating Brown Adipose Tissue (BAT) activation and differentiation in a subject, the method comprising contacting one or more cells in the subject with a composition comprising one or more exogenous miRNA-455 selected from the group consisting of [SEQ ID NOs: 1-4], the cells being selected from the group consisting of brown adipose cells, white adipose cells and preadipocytes.