DRUG LOADED NANO ANTI-ADHERING MEMBRANE WITH CORE/SHELL STRUCTURE AND PREPARATION METHOD THEREOF

摘要

Disclosed is a drug loaded nano anti-adhering membrane with a core/shell structure and a preparation method thereof. The drug loaded nano anti-adhering membrane with a core/shell structure is formed by connecting fibers of a core and a shell structure in parallel, wherein the core comprises a therapeutically effective amount of an active ingredient and polyvinylpyrrolidone(PVP); the shell is of poly (lactic-co-glycolic acid) (PLGA), and micropores are provided on the shell. The drug loaded nano anti-adhering membrane with a core/shell structure has a preparation method which is easy, simple and efficient and the cost of which is low, wherein the membrane material prepared has a very good controllable specific surface area, a controllable pore size, mechanical properties, blood osmosis properties and a controllable biodegradability, and when preventing adhesion, causes no hypersensitivity to humans, while having affinities with blood and surrounding tissues in the human body, and having a bioadhesive surface and not rejecting.