| 主权项 |
1. A compound having the general formula 8: wherein
n1 is a number from 0 to 4;n2 is a number from 1 to 7;R1 is H; linear or branched C1-C6 alkyl; propargyl, cyclopropylmethyl, but-2-en-1-yl, γ-methylallyl, β-methylallyl, γ,γ-dimethylallyl, benzyl, allyl, pyridin-ylmethyl;methylcarbamoyl, ethylcarbamoyl, propylcarbamoyl, or prop-2-enylcarbamoyl;R2 is H or R3 is OH, nitro, NH2, NHR8, NR9R10, C1-C6 alkyl, COOH, CONH2, CONR11H, CONR12R13, cyano, F, Cl, Br;wherein R8, R9, R10, R11, R12, R13, are the same or each independently C1-C6 alkyl, methylcyclopropyl or propan-2-yl;X is CH2 or C(=0);Y is CH2,or X—Y is wherein R4, R5, R6, R7 are the same or each independently H, OH, nitro, NH2, NHR14, NR15R16, C1-C6 alkyl, COOH, CONH2, CONR17H, CONR18R19, cyano, F, Cl, Br;wherein R14, R15, R16, R17, R18, R19 are the same or each independently C1-C6 alkyl, methylcyclopropyl or propan-2-yl;Z is CH2, or pharmaceutically acceptable salts thereof. |
