发明名称 |
TRIBLOCK COPOLYMERS FOR CYTOPLASMIC DELIVERY OF GENE-BASED DRUGS |
摘要 |
The invention features a triblock copolymer including a hydrophilic block; a hydrophobic block; and a positively charged block capable of reversibly complexing a negatively charged molecule, e.g., a nucleic acid, wherein the hydrophobic block is disposed between the hydrophilic block and the positively charged block. Desirably, the triblock copolymer is capable of self-assembling into a supramolecular structure, such as a micelle or vesicle. The invention further features methods of delivering negatively charged molecules and methods of treating a disease or condition using the polymers of the invention. |
申请公布号 |
EP1891141(A2) |
申请公布日期 |
2008.02.27 |
申请号 |
EP20060799931 |
申请日期 |
2006.05.31 |
申请人 |
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE |
发明人 |
SEGURA, TATIANA;HUBBELL, JEFFREY, A. |
分类号 |
C08G63/91;A61K9/127;C08F283/00 |
主分类号 |
C08G63/91 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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