发明名称 |
SUSTAINED RELEASE ENCAPSULATED NANOPARTICLES |
摘要 |
The present invention provides a microparticle comprising at least one biocompatible polymer, the microparticle encapsulating at least one nanoparticle, the nanoparticle comprising: (i) a core comprising a metal and/or a semiconductor; and (ii) a corona comprising a plurality of ligands covalently linked to the core, wherein said ligands comprise at least one carbohydrate and/or glutathione. The nanoparticle may additionally comprise a biologically active agent or detectable label covalently linked or non-covalently bound to said corona and/or said core. Also disclosed are pharmaceutical compositions comprising the microparticles, processes for their production and uses of the microparticles in methods of therapy. |
申请公布号 |
WO2016075211(A1) |
申请公布日期 |
2016.05.19 |
申请号 |
WO2015EP76364 |
申请日期 |
2015.11.11 |
申请人 |
MIDATECH LIMITED;MIDATECH PHARMA (WALES) LIMITED |
发明人 |
WILLIAMS, PHILLIP;GROVES, RHIAN;PALMER, DANIEL |
分类号 |
A61K9/00;A61K9/16;A61K9/51;A61K47/34;A61K47/48 |
主分类号 |
A61K9/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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