| 发明名称 |
Biomarkers of Response to Inhibition of Poly-ADP Ribose Polymerase (PARP) in Cancer |
| 摘要 |
Provided herein are methods of identifying a subject having a poly-ADP ribose polymerase (PARP) inhibitor-sensitive tumor by detecting a genomic gain in chromosome 1q21 and/or chromosome 20q13.3 in a tumor sample from the subject. Also provided are methods of identifying a subject having a PARP inhibitor-sensitive tumor by detecting gene amplification of a CHD1L gene or an RTEL1 gene in a tumor sample from the subject. Further provided are methods of treating a tumor with a genomic gain in chromosome 1q21 and/or chromosome 20q13.3 in a subject by administering an effective dose of a PARP inhibitor. |
| 申请公布号 |
US2016138114(A1) |
申请公布日期 |
2016.05.19 |
| 申请号 |
US201414899974 |
申请日期 |
2014.06.18 |
| 申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
Slamon Dennis;Finn Richard;Conklin Dylan |
| 分类号 |
C12Q1/68;G01N33/574;A61K45/06;A61K31/5025 |
主分类号 |
C12Q1/68 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of identifying a subject having a poly-ADP ribose polymerase (PARP) inhibitor-sensitive tumor, comprising,
detecting a genomic gain in chromosome 1q21 and/or chromosome 20q13.3 in a tumor sample from the subject, wherein the genomic gain is indicative of a tumor that is sensitive to PARP inhibitors. |
| 地址 |
Oakland CA US |
