发明名称 |
BIOACTIVE POLYPEPTIDE MONOMER-IMMUNOGLOBULIN FC FRAGMENT CONJUGATE HAVING DECREASED RECEPTOR-MEDIATED CLEARANCE, AND METHOD FOR PREPARING SAME |
摘要 |
The present invention relates to: a long-acting pharmaceutical composition containing a conjugate comprising a physiologically active polypeptide linked to an immunoglobulin Fc fragment, wherein the composition contains a monomeric conjugate comprising one molecule of the physiologically active polypeptide linked to a single immunoglobulin Fc fragment, and optionally contains a multimeric conjugate comprising two or more molecules of the same physiologically active polypeptide linked to a single immunoglobulin Fc fragment, provided that the molar ratio of the monomeric conjugate to the multimeric conjugate in the composition is at least 19; a physiologically active polypeptide monomer-immunoglobulin Fc fragment conjugate that comprises a physiologically active polypeptide monomer linked via a non-peptidyl linker to an immunoglobulin Fc fragment, wherein the physiologically active polypeptide is linked via the non-peptidyl linker to the immunoglobulin Fc fragment in a monomeric form, the conjugate showing reduced receptor-mediated internalization or receptor-mediated clearance compared to either a dimeric conjugate comprising two molecules of the physiologically active polypeptide linked via the non-peptidyl linker to a single immunoglobulin Fc fragment, or a conjugate comprising a physiologically active polypeptide dimer linked in-frame to the immunoglobulin Fc fragment; and a method for preparing the long-acting pharmaceutical composition. |
申请公布号 |
EP3020418(A1) |
申请公布日期 |
2016.05.18 |
申请号 |
EP20140823791 |
申请日期 |
2014.07.14 |
申请人 |
HANMI PHARM. CO., LTD. |
发明人 |
PARK, SUNG HEE;KIM, MIN YOUNG;LIM, HYUNG KYU;BAE, SUNG MIN;JUNG, SUNG YOUB;KWON, SE CHANG |
分类号 |
C07K14/62 |
主分类号 |
C07K14/62 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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