| 发明名称 | Morphinan compounds | ||
| 摘要 | This invention relates to novel morphinan compounds and pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering a σ1 receptor agonist that also has NMDA antagonist activity. | ||
| 申请公布号 | US9340512(B2) | 申请公布日期 | 2016.05.17 |
| 申请号 | US201514726758 | 申请日期 | 2015.06.01 |
| 申请人 | Concert Pharmaceuticals, Inc. | 发明人 | Graham Philip B.;Silverman I. Robert |
| 分类号 | A61K31/485;C07D221/28;A61K45/06 | 主分类号 | A61K31/485 |
| 代理机构 | Fish & Richardson P.C. | 代理人 | Fish & Richardson P.C. |
| 主权项 | 1. A compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein: R1 is —(C1-C4)alkyl, wherein R1 is optionally substituted with one or more deuterium atoms; and R2 is selected from CH3, CH2D, CHD2, and CD3; provided that at least one deuterium atom is present at either R1 or R2. | ||
| 地址 | Lexington MA US | ||