Chromatographic material and method for preparation thereof

摘要

A chromatographic material comprising a zwitterionic ligand covalently bound to a substrate, the ligand preferably has a formula II:;
wherein

R1, R2, R3 are independently selected from an oxygen atom that is configured to connect to a substrate atom in the substrate, an oxygen atom that is configured to connect to a silicon atom of an adjacent ligand, a hydroxyl group, a halogen atom, an alkoxy group, a dialkylamino group, an acyl group, an alkyl group, or an aryl group;

L1, L2 and L3 are independently hydrophobic moieties; each containing 2 to 30 carbon atoms, wherein there are at least 10 carbon atoms in the combined chain lengths of L1, L2 and L3;

X is an O atom, S atom, amide group or sulfonamide group;

n is 0 or 1;

R4, R5 are independently selected from a hydrogen atom or a hydrocarbon moiety containing 1 to 20 carbon atoms; and

Rf is a negatively charged moiety comprising a sulfonic, carboxylic, or phosphonic functional group.

主权项

1. A chromatographic material comprising a zwitterionic ligand covalently bound to a substrate, wherein the zwitterionic ligand has a general formula I: wherein the zwitterionic ligand is covalently bound to the substrate through the silyl group, the ionic groups have opposite charges to each other, and there are at least 10 carbon atoms in the combined chain lengths of the hydrophobic linkers, wherein at least one of the hydrophobic linkers comprises a homoalkyl group having at least 8 carbon atoms in the chain.