| 发明名称 | Arginine-based lipids for delivery of therapeutics | ||
| 摘要 | This disclosure provides a range of amino acid lipid compounds and compositions useful for drug delivery, therapeutics, and the diagnosis and treatment of diseases and conditions. The amino acid lipid compounds and compositions can be used for delivery of various agents such as nucleic acid therapeutics to cells, tissues, organs, and subjects. | ||
| 申请公布号 | US9339461(B2) | 申请公布日期 | 2016.05.17 |
| 申请号 | US201414496200 | 申请日期 | 2014.09.25 |
| 申请人 | Marina Biotech, Inc. | 发明人 | Quay Steven C.;Houston, Jr. Michael E.;Harvie Pierrot;Adami Roger C.;Fam Renata;Prieve Mary G.;Fosnaugh Kathy L.;Seth Shaguna |
| 分类号 | A61K47/18;A61K48/00;C07C279/12;A61K9/127;C07D213/56;C07C279/14;C07D213/40;C07D233/26;C12N15/11;C12N15/88;A61K47/44;C12N15/113;A61K31/7088;A61K47/22;C07D233/64 | 主分类号 | A61K47/18 |
| 代理机构 | Eckman Basu LLP | 代理人 | Eckman Basu LLP |
| 主权项 | 1. A compound comprising the structure shown in Formula I: R3—(C═O)-Xaa-Z—R4 Formula Iwherein Xaa is nor-norarginine or homoarginine; R3 is independently a substituted or unsubstituted C(12-22)alkyl or C(12-22)alkenyl; R4 is independently a substituted or unsubstituted C(12-22)alkyl or C(12-22)alkenyl; Z is NH;and salts thereof. | ||
| 地址 | Bothell WA US | ||