发明名称 |
Notch1 receptor binding agents and methods of use thereof |
摘要 |
Means and methods for the diagnosis, characterization, prognosis and treatment of cancer, specifically targeting cancer stem cells are disclosed Provided is an antibody that specifically binds to a non-ligand binding membrane proximal region of the extracellular domain of a human Notch receptor and inhibits tumor growth, and a method of treating cancer comprising administering said antibody to a subject. |
申请公布号 |
AU2009269096(B2) |
申请公布日期 |
2016.05.12 |
申请号 |
AU20090269096 |
申请日期 |
2009.07.08 |
申请人 |
ONCOMED PHARMACEUTICALS, INC. |
发明人 |
AXELROD, FUMIKO TAKADA;HOEY, TIMOTHY CHARLES;BRUHNS, MAUREEN FITCH;GURNEY, AUSTIN L. |
分类号 |
A61K39/395 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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