| 主权项 |
1. A compound of formula (I): or a pharmaceutically acceptable salt, ester, amide, or radiolabelled form thereof, wherein: R1 is hydrogen or C1-C4-alkyl; R2, at each occurrence, is independently hydrogen or C1-C4-alkyl; R3, at each occurrence, is independently hydrogen or methyl; R4, at each occurrence, is independently hydrogen, alkyl, alkenyl, alkynyl, cyano, cyanoalkyl, halogen, haloalkyl, —ORx, —OC(O)Rx. —OC(O)N(Rx)(Ry), —SRy, —S(O)Rw, —S(O)2Rw, —S(O)2N(Rx)(Ry), —C(O)Rw, —C(O)ORy, —C(O)N(Rx)(Ry), —N(Rx)(Ry), —N(Rx)C(O)Rw, —N(Rx)C(O)O(Rv), or —N(Rx)S(O)2(Rw); Rv, Rw, Rx, and Ry, at each occurrence, are independently hydrogen, alkyl, or haloalkyl; L1 is O or S; G1 is phenyl or monocyclic heteroaryl, wherein G1 is unsubstituted or substituted with 1, 2, 3, or 4 substituents selected from C1-C4-alkyl, C1-C4-fluoroalkyl or fluoro; G2 is selected from (i) or (ii), wherein, R5, R6, R7 and R8 are, at each occurrence, independently selected from the group consisting of hydrogen, alkyl, cycloalkyl, fluoroalkyl, and hydroxyalkyl; R9 and R10 are, at each occurrence, independently selected from the group consisting of hydrogen, alkyl, alkoxy, alkylamino, dialkylamino, fluoro, hydroxy, and hydroxyalkyl; R11, R12, R13 and R14 are, at each occurrence, independently selected from the group consisting of hydrogen, alkyl, fluoroalkyl, and hydroxyalkyl; Q is selected from the group consisting of a bond, O, S, and NR15; wherein R15 is hydrogen, alkyl, —C(O)Rw, or —C(O)N(Rx)(Ry); m is 2, 3, 4, 5 or 6; n is 1, 2, 3, 4, or 5; and p is 0 and q is 0; or p is 1 and q is 1; or p is 1 and q is 0. |
