发明名称 |
RSPO binding agents and uses thereof |
摘要 |
Abstract RSPO binding agents and uses thereof The present invention relates to RSPO-binding agents and methods of using the agents for treating diseases such as cancer. The present invention provides antibodies that specifically bind human RSPO proteins and modulate B-catenin activity. The present invention further provides methods of using agents that modulate the activity of RSPO proteins, such as antibodies that specifically bind RSPO1, RSPO2, and/or RSPO3 and inhibit tumor growth. Also described are methods of treating cancer comprising administering a therapeutically effect amount of an agent or antibody of the present invention to a patient having a tumor or cancer. |
申请公布号 |
AU2013204484(B2) |
申请公布日期 |
2016.05.12 |
申请号 |
AU20130204484 |
申请日期 |
2013.04.12 |
申请人 |
ONCOMED PHARMACEUTICALS, INC. |
发明人 |
GURNEY, AUSTIN L.;AXELROD, FUMIKO TAKADA;HOEY, TIMOTHY CHARLES;CHARTIER-COURTAUD, CECILE |
分类号 |
A61K39/395;G01N33/574 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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地址 |
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