发明名称 |
METHODS AND SYSTEMS FOR O-GLYCOSYLATING PROTEINS |
摘要 |
Described herein are methods and systems for O-glycosylating proteins in vivo or in vitro in any prokaryotic organism. In these methods and systems, DNA comprising a gene that produces a PglL-like oligosaccharyltransferase and DNA comprising a gene that produces a protein to be O-glycosylated are used. The PglL-like oligosaccharyltransferase facilitates the covalent attachment of the glycan to the protein to produce the O-glycosylated protein. The methods and systems described herein provide an approach for the design and production of new vaccines and therapeutic agents for the treatment of various diseases. |
申请公布号 |
EP2142660(A2) |
申请公布日期 |
2010.01.13 |
申请号 |
EP20070872469 |
申请日期 |
2007.12.13 |
申请人 |
THE GOVERNORS OF THE UNIVERSITY OF ALBERTA |
发明人 |
FELDMAN, MARIO;FARIDMOAYER, AMIRREZA |
分类号 |
C12P21/02;A61K38/16;A61K39/02;A61K39/095;A61P31/04;A61P37/04;C07K9/00;C12N15/00;C12N15/63 |
主分类号 |
C12P21/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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