SMALL MOLECULE INHIBITORS OF NECROPTOSIS,申请号AU20160202262-传众专利搜索

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发明名称	SMALL MOLECULE INHIBITORS OF NECROPTOSIS
摘要	The invention features a series of heterocyclic derivatives that inhibit tumor necrosis factor alpha (TNF-a) induced necroptosis. The heterocyclic compounds of the invention are described by Formulas (I)-(VIll) and by Compounds (l)-(l), (13)-(26), (27)-(33), (48)-(57), and (58)-(70). These necrostatins are shown to inhibit TNF-a induced necroptosis in FADD deficient variant of human Jurkat T cells. The invention further features pharmaceutical compositions featuring necrostatins. The compounds and compositions of the invention may also be used to treat disorders where necroptosis is likely to play a substantial role.
申请公布号	AU2016202262(A1)	申请公布日期	2016.05.12
申请号	AU20160202262	申请日期	2016.04.12
申请人	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	发明人	YUAN, JUNYING;HSU, EMILY S.
分类号	C07D495/04;A01N43/40;A61K31/44	主分类号	C07D495/04
代理机构		代理人
主权项
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