Hepatitis B virus specific antibody and uses thereof

摘要

There is provided at least one isolated TCR-like antibody or fragment thereof, wherein the antibody or fragment thereof is capable of specifically binding to at least one HBV derived peptide.

主权项

1. An isolated TCR-like antibody or fragment thereof, wherein the antibody or fragment thereof is specifically binding to at least one HBV derived peptide, wherein the HBV derived peptide comprises HBe183-191 of SEQ ID NO: 24 and is part of a HLA-A2 peptide complex, the complex comprising the HBV derived peptide and a HLA-A2 molecule, wherein the antibody is selected form the group consisting of:
a) an antibody produced by hybridoma cell line deposited with ATCC with accession number PTA-11068 and b) an antibody comprising at least one light chain and at least one heavy chain, wherein the light chain comprises the amino acid sequence of SEQ ID NO: 32, and the heavy chain comprises the amino acid sequence of SEQ ID NO: 33, wherein the antibody is capable of distinguishing HBV-infected cells from uninfected cells.