| 主权项 |
1. A method of closing an opening in a vessel wall of a body comprising:
positioning a deployment apparatus relative to the opening in the vessel wall, the deployment apparatus having a lumen extending therethrough, a tissue closure device being positioned within the lumen, the tissue closure device having a hub extending along a central longitudinal axis between a proximal surface and an opposing distal surface, a first annular flange extending from the hub adjacent the proximal surface, and a second annular flange extending from the hub adjacent the distal surface, the first flange including a first biasing element completely encapsulated by the first flange, the first biasing element is a single layer of wire mesh, the first and second flanges extending longitudinally away from the hub in opposite directions from each other and being substantially parallel with the central longitudinal axis such that the flanges generally form a cylinder and a continuous terminal edge of each flange forms each end of the cylinder, wherein the second flange does not have a biasing element; expelling the tissue closure device from the lumen and into the opening in the vessel wall, thereby causing the first and second flanges to extend radially away from the hub and to be substantially orthogonal to the central longitudinal axis so as to bound a channel therebetween that receives and seals the vessel wall that bounds the opening, the biasing force of the first flange against the vessel wall sufficient to seal the vessel wall being greater than the biasing force imposed by the first biasing element; and removing the deployment apparatus from the body. |
