| 主权项 |
1. A compound of Formula (I): where:
X is —NH;S, T and U are independently —CR3— or —N—; selected from: A is phenyl;
R1 is hydrogen, alkyl, haloalkyl, substituted alkyl, or cycloalkyl, wherein said cycloalkyl is optionally substituted with one to three substituents-independently selected from alkyl, halo, haloalkyl, alkoxy, hydroxyl, or haloalkoxy;R1a is hydrogen;R2 is hydrogen, alkyl, substituted alkyl, aryl, heteroaryl, cycloalkyl, halo, haloalkyl, haloalkoxy, alkoxy, alkoxyalkoxy, hydroxy, carboxy, alkoxycarbonyl, cyano, amino, monosubstituted or disubstituted amino, sulfonyl, or alkoxyalkyl;each R3 is hydrogen;R4 is hydrogen, alkyl, substituted alkyl, halo, alkoxy, hydroxy, carboxy, —CONH2, —CONMe2, cycloalkyl, or dialkylamino;R5 and R6 together with the nitrogen atom to which they are attached form ring B having the formula: wherein ring B is a heterocyclyl ring-selected from:
a) azetidin-1-yl, pyrrolidin-1-yl, piperidin-1-yl or piperazin-1-yl;b) 1,2,3,4-tetrahydroisoquinolin-2-yl substituted with Rb at 6-position with haloalkoxy, cyano, cycloalkyl, halo, alkoxy, haloalkyl, or alkoxyalkoxy; orc) 3,6-dihydro-1(2H)-pyridinyl;wherein each aforementioned ring B is substituted with Ra, Rb or Rc;wherein Ra is hydrogen, alkyl, halo, haloalkyl, haloalkoxy, alkylthio, haloalkylthio, cyano, hydroxy, alkoxy, amino, monosubstituted amino, disubstituted amino, sulfonyl, thio, acyl, carboxy, alkoxycarbonyl, hydroxyalkyl, alkoxyalkyl, aminoalkyl, hydroxyalkoxy, hydroxyalkoxyalkyl, alkoxyalkoxy, aminoalkoxy, aminosulfonyl, aminocarbonyl, or acylamino andRb and Rc are independently selected from hydrogen, alkyl, substituted alkyl, substituted alkynyl, halo, haloalkyl, haloalkoxy, alkylthio, cyano, alkoxy, amino, monosubstituted amino, disubstituted amino, sulfonyl, acyl, carboxy, alkoxycarbonyl, hydroxyalkyl, alkoxyalkyl, aminoalkyl, hydroxyalkoxy, alkoxyalkoxy, aminoalkoxy, aminosulfonyl, aminocarbonyl, acylamino, sulfonylamino, aryl, heteroaryl, cycloalkyl, cycloalkenyl, heterocyclyl, aralkyl, heteroaralkyl, heterocyclylalkyl, aryloxy, heteroaryloxy, cycloalkoxy, aryloxyalkyl, aralkyloxy, aralkyloxyalkyl, aralkylthio, heteroaralkyloxy, heterocyclylalkyloxy, cycloalkylalkyloxy or cycloalkylalkyloxyalkyl;where the aromatic or alicyclic ring in Ra, Rb and Rc is optionally substituted with Rd, Re or Rf which are independently selected from alkyl, halo, haloalkyl, haloalkoxy, cyanoalkyl, alkylthio, cyano, hydroxy, alkoxy, amino, monosubstituted amino, disubstituted amino, sulfonyl, acyl, carboxy, alkoxycarbonyl, hydroxyalkyl, alkoxyalkyl, aminoalkyl, hydroxyalkoxy, alkoxyalkoxy, aminoalkoxy, aminosulfonyl, aminocarbonyl, acylamino, cycloalkyl, cycloalkenyl, phenyl, phenoxy, heteroaryl, heterocyclyl, heterocyclylalkyl, aralkyl, aralkyloxy or heteroaralkyl and where the aromatic or alicyclic ring in Rd, Re or Rf is optionally substituted with one to three substituents independently selected from alkyl, halo, haloalkyl, haloalkyloxy, hydroxyl, alkoxy, acetylamino, alkylsulfonyl, or cyano; or a pharmaceutically acceptable salt thereof; provided that the compound is not 3-((4-((3S)-3-benzyl-1-piperidinyl)-1,3,5-triazin-2-yl)amino)-N-methylbenzamide; 3-((4-((3R)-3-benzyl-1-piperidinyl)-1,3,5-triazin-2-yl)amino)-N-methylbenzamide; or N-methyl-3-((4-(4-(4-morpholinylcarbonyl)-1-piperidinyl)-1,3,5-triazin-2-yl)amino)benzamide. |
