AURISTATIN ANALOGUES AND THEIR CONJUGATES WITH CELL-BINDING MOLECULES

摘要

Provided are analogues of auristatins, in particular monomethyl auristatin F (MMAF), as cytotoxic agents, conjugates of such agents with a cell-binding agent, the preparation and the therapeutic uses of these cytotoxic agents and conjugates thereof to arrest or retard abnormal cell growth and /or proliferation.