发明名称 |
TREATMENT OF PEDIATRIC BCP-ALL PATIENTS WITH AN ANTI-KIR ANTIBODY |
摘要 |
This disclosure provides a method for treating a pediatric subject afflicted with acute B cell precursor leukemia (BCP-ALL) comprising administering to the subject an anti-killer cell immunoglobulin-like receptor (KIR) antibody or an antigen-binding portion thereof that binds specifically to an inhibitory KIR and blocks inhibitory KIR activity, thereby potentiating NK cell lytic activity. An exemplary anti-KIR antibody for use in this method is lirilumab. The disclosure also provides a kit for treating a subject afflicted with pediatric BCP-ALL, the kit comprising a dosage ranging from 0.01 to 20 mg/kg body weight of an anti-KIR antibody or an antigen-binding portion thereof that specifically binds to an inhibitory KIR and blocks inhibitory KIR activity, and instructions for using the anti-KIR antibody or an antigen-binding portion thereof in any of the disclosed methods for treating pediatric BCP-ALL. |
申请公布号 |
WO2016069589(A1) |
申请公布日期 |
2016.05.06 |
申请号 |
WO2015US57565 |
申请日期 |
2015.10.27 |
申请人 |
UNIVERSITY CHILDREN'S HOSPITAL TÜBINGEN |
发明人 |
ANDRÉ, MAYA CAROLINE;KÜBLER, AYLINE |
分类号 |
A61K39/395;A61K35/17;C07K16/28 |
主分类号 |
A61K39/395 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|