| 发明名称 |
VACCINE STABILIZER |
| 摘要 |
Disclosed herein is a formulation capable of enhancing thermostability and shelf-life of a biological product, the formulation comprising: a tertiary amine N-oxide or a derivative thereof represented by the formulae:;;wherein R1, R2, and R3 may be identical or different and each is a straight or branched lower alkyl group having from 1 to 4 carbon atoms; an inorganic salt; glutamic acid or a salt thereof; a polyol; a physiologically acceptable buffer, and a pharmaceutically acceptable carrier. The tertiary amine N-oxide may be trimethylamine-N-oxide, (CH3)3NO. The formulation is useful for vaccine stabilization. |
| 申请公布号 |
US2016120982(A1) |
申请公布日期 |
2016.05.05 |
| 申请号 |
US201614992350 |
申请日期 |
2016.01.11 |
| 申请人 |
GE Healthcare Bio-Sciences Corp. |
发明人 |
Sun Tianxiao;Levesque Philip M.;Brown Alicja T.;Lee Cynthia K. |
| 分类号 |
A61K47/18;A61K39/12 |
主分类号 |
A61K47/18 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A formulation capable of enhancing thermostability and shelf-life of a biological product, the formulation comprising: a tertiary amine N-oxide or a derivative thereof represented by the formulae:wherein R1, R2, and R3 may be identical or different and each is a straight or branched lower alkyl group having from 1 to 4 carbon atoms; an inorganic salt; glutamic acid or a salt thereof; a polyol; a physiologically acceptable buffer, and a pharmaceutically acceptable carrier. |
| 地址 |
Marlborough MA US |
