发明名称 |
Oncolytic adenoviruses armed with heterologous genes |
摘要 |
The present disclosure relates to a group B adenovirus comprising a sequence of formula (I): 5'ITR-B1-BA-B2-BX-BB-BY-B3-3'ITR wherein: B1 is bond or comprises: E1A, E1B or E1A-E1B; BA comprises-E2B-L1-L2-L3-E2A-L4; B2 is a bond or comprises: E3; BX is a bond or a DNA sequence comprising: a restriction site, one or more transgenes or both; BB comprises L5; BY is a bond or a DNA sequence comprising: a restriction site, one or more transgenes or both; B3 is a bond or comprises: E4; wherein at least one of BX or BY is not a bond, pharmaceutical compositions comprising the same and use of the viruses and compositions in treatment, particularly in the treatment of cancer. The disclosure also extends to plasmids and processes employed to prepare the said viruses. |
申请公布号 |
GB2531821(A) |
申请公布日期 |
2016.05.04 |
申请号 |
GB20140020267 |
申请日期 |
2014.10.24 |
申请人 |
Psioxus Therapeutics Limited |
发明人 |
Brian Robert Champion;Alice Claire Noel Brown;Kerry David Fisher;Tamara Jane Nicolson |
分类号 |
C12N7/00;A61K35/761;A61K48/00;C12N15/861 |
主分类号 |
C12N7/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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