| 发明名称 | Multimeric IL-15 soluble fusion molecules and methods of using same | ||
| 摘要 | The present invention features compositions and methods featuring ALT-803, a complex of an interleukin-15 (IL-15) superagonist mutant and a dimeric IL-15 receptor α/Fc fusion protein useful for enhancing an immune response against a neoplasia (e.g., multiple myeloma, melanoma, lymphoma) or a viral infection (e.g., human immunodeficiency virus). | ||
| 申请公布号 | US9328159(B2) | 申请公布日期 | 2016.05.03 |
| 申请号 | US201313854903 | 申请日期 | 2013.04.01 |
| 申请人 | Altor Bioscience Corporation | 发明人 | Wong Hing C.;Rhode Peter;Liu Bai;Zhu Xiaoyun;Han Kai-ping |
| 分类号 | C07K14/715;C07K14/54;C07K16/18;A61K38/20;A61K38/00 | 主分类号 | C07K14/715 |
| 代理机构 | Mintz Levin Cohn Ferris Glovsky and Popeo, P.C. | 代理人 | Mintz Levin Cohn Ferris Glovsky and Popeo, P.C. ;Corless, Esq. Peter F.;Clarke Daniel W. |
| 主权项 | 1. A kit for the treatment of a neoplasia, the kit comprising an effective amount of an IL-15N72D:IL-15RαSu/Fc complex (Alt-803) comprising a dimeric IL-15RαSu/Fc and two IL-15N72D molecules and directions for its use, wherein said neoplasia is selected from the group consisting of multiple myeloma, beta-cell lymphoma, urothelial/bladder carcinoma and melanoma. | ||
| 地址 | Miramar FL US | ||