Human antibodies that bind human MAdCAM

摘要

The present invention relates to antibodies, including human antibodies, and antigen-binding portions thereof that specifically bind to MAdCAM, preferably human MAdCAM, and inhibit MAdCAM. The antibodies comprise the CDRs or variable domains derived from an antibody produced by the hybridoma cell line 7.16.6 (ECACC Accession No. 03090909) or from an antibody comprising the amino acid sequences of SEQ ID NOs.: 34 and 36. The invention also relates to nucleic acid molecules encoding such antibodies and antigen-binding portions thereof, methods of making and using the antibodies and portions, and compositions comprising these antibodies and portions.

主权项

1. A human monoclonal antibody that specifically binds to MAdCAM, wherein the antibody comprises the amino acid sequences in SEQ ID NO: 34 and SEQ ID NO: 36 without the signal sequences; and wherein the antibody possesses at least one of the following properties:
(a) has a selectivity for MAdCAM over VCAM or fibronectin of at least 100 fold; (b) binds to human MAdCAM with a Kd of 3×10−10 M or less; and (c) inhibits the binding of α4β7 expressing cells to human MAdCAM.