| 发明名称 |
COMPOSITION FOR APPLICATION TO A MUCOSA COMPRISING A METHYLCELLULOSE |
| 摘要 |
A composition designed for application to a mucosa comprises a tonicity-adjusting agent, a methylcellulose, and a liquid diluent, wherein the methylcellulose has anhydroglucose units joined by 1-4 linkages wherein hydroxy groups of anhydroglucose units are substituted with methyl groups such that s23/s26 is 0.36 or less, wherein s23 is the molar fraction of anhydroglucose units wherein only the two hydroxy groups in the 2- and 3-positions of the anhydroglucose unit are substituted with methyl groups and wherein s26 is the molar fraction of anhydroglucose units wherein only the two hydroxy groups in the 2- and 6-positions of the anhydroglucose unit are substituted with methyl groups. |
| 申请公布号 |
US2016114047(A1) |
申请公布日期 |
2016.04.28 |
| 申请号 |
US201414890617 |
申请日期 |
2014.07.16 |
| 申请人 |
DOW GLOBAL TECHNOLOGIES LLC |
发明人 |
Curtis-Fisk Jaime;Jordan Susan L.;Rogers True L.;Knarr Matthias;Brackhagen Meinolf;Adden Roland |
| 分类号 |
A61K47/38;A61K47/02;A61K31/167;A61K9/00 |
主分类号 |
A61K47/38 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A composition for application to a mucosa comprising a tonicity-adjusting agent, a methylcellulose, and a liquid diluent, wherein the methylcellulose has anhydroglucose units joined by 1-4 linkages wherein hydroxy groups of anhydroglucose units are substituted with methyl groups such that s23/s26 is 0.36 or less,
wherein s23 is the molar fraction of anhydroglucose units wherein only the two hydroxy groups in the 2- and 3-positions of the anhydroglucose unit are substituted with methyl groups and wherein s26 is the molar fraction of anhydroglucose units wherein only the two hydroxy groups in the 2- and 6-positions of the anhydroglucose unit are substituted with methyl groups and the tonicity-adjusting agent is sodium chloride, potassium chloride, calcium chloride, a buffering agent, xylitol, glycerin, mannitol or sorbitol. |
| 地址 |
Midland MI US |
