发明名称 NARGENICIN COMPOUNDS AND USES THEREOF AS ANTIBACTERIAL AGENTS
摘要 The present invention relates to novel nargenicin related compounds which can inhibit DnaE and have antibacterial, particularly antimycobacterial activity against Mycobacterium tuberculosis. The present invention also relates to method for inhibiting growth of mycobacterial cells as well as a method of treating mycobacterial infections by Mycobacterium tuberculosis by administering an antimycobacterially effective amount of nargenicin or a nargenicin-related compound and/or their pharmaceutically acceptable salts.
申请公布号 WO2016064982(A1) 申请公布日期 2016.04.28
申请号 WO2015US56627 申请日期 2015.10.21
申请人 MERCK SHARP & DOHME CORP.;YOUNG, KATHERINE;OLSEN, DAVID, B.;SINGH, SHEO, B.;SU, JING;WILKENING, ROBERT, R.;APGAR, JAMES, M.;MENG, DONGFANG;PARKER, DANN;MANDAL, MIHIR;YANG, LIHU;PAINTER, RONALD, E.;DANG, QUN;SUZUKI, TAKAO 发明人 YOUNG, KATHERINE;OLSEN, DAVID, B.;SINGH, SHEO, B.;SU, JING;WILKENING, ROBERT, R.;APGAR, JAMES, M.;MENG, DONGFANG;PARKER, DANN;MANDAL, MIHIR;YANG, LIHU;PAINTER, RONALD, E.;DANG, QUN;SUZUKI, TAKAO
分类号 C07D493/10 主分类号 C07D493/10
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