PHARMACEUTICAL COMPOSITION FOR TREATING ISCHEMIA CONTAINING GLUTAREDOXIN FUSION PROTEIN

摘要

The present invention relates to a pharmaceutical composition for treating cerebral ischemia, containing a cell-permeable glutaredoxin (GLRX) fusion protein. The GLRX fusion protein penetrated into cells increases the cell survival rate under the toxicity of hydrogen peroxide, while reducing the DNA fragmentation induced by hydrogen peroxide and the level of intracellular active oxygen species. In an animal model, the GLRX fusion protein of the present invention has shown protective effects with respect to neuronal cell death taking place after induction of temporary ischemia on a region of hippocampal CA1 in the forebrain. Such results indicate that the GLRX fusion protein has protective effects on the cell death and treating effects by protecting neural cells from the ischemia damage.