| 发明名称 | Antibodies that specifically bind SOST and WISE peptides | ||
| 摘要 | The present invention is directed to isolated polypeptides and antibodies suitable for producing therapeutic preparations, methods, and kits relating to bone deposition. One objective of the present invention is to provide compositions that improve bone deposition. Yet another objective of the present invention is to provide methods and compositions to be utilized in diagnosing bone dysregulation. The therapeutic compositions and methods of the present invention are related to the regulation of Wise, Sost, and closely related sequences. In particular, the nucleic acid sequences and polypeptides include Wise and Sost as well as a family of molecules that express a cysteine knot polypeptide. | ||
| 申请公布号 | US9321835(B2) | 申请公布日期 | 2016.04.26 |
| 申请号 | US201314012626 | 申请日期 | 2013.08.28 |
| 申请人 | Stowers Institute for Medical Research | 发明人 | Krumlauf Robb;Ellies Debra |
| 分类号 | C07K16/00;C07K16/18;C07K16/22;C07K16/24;C07K14/47;C07K14/705;C12N5/12;C12N15/13;A61K38/00;A61K48/00;A61K39/00 | 主分类号 | C07K16/00 |
| 代理机构 | Bryan Cave LLP | 代理人 | Bryan Cave LLP |
| 主权项 | 1. An isolated monoclonal antibody that specifically binds to the amino acid sequence selected from the group consisting of SEQ ID NOs: 98, 101, and 105. | ||
| 地址 | Kansas City MO US | ||