| 主权项 |
1. A compound of formula Ia: wherein A is phenyl optionally substituted with C1-C4 alkyl, halogen, OH, CN, or N(R4)2; R1 is absent, H, OH, halogen, N(R4)2, O-alkyl, CN, —S(O)2-alkyl, —O—C1-C4 alkyl optionally substituted with halogen, OH, O-alkyl, CN, or N(R4)2, or C1-C4 alkyl optionally substituted with halogen, OH, O-alkyl, CN, or N(R4)2; R2 and R3 are independently selected from H, halogen, or C1-C4 alkyl optionally substituted with halogen, OH, CN, N(R4)2, or R2 and R3, taken together may form a 4-7 membered saturated or unsaturated ring, optionally incorporating 1-3 N, O, or S atoms; wherein the 4-7 membered ring is optionally substituted with C1-C4 alkyl, halogen, OH, carbonyl, CN, halogen, or N(R4)2, or R2 and R3, can be taken together to form a carbonyl; each R4 is independently H, alkyl, aryl, or can be taken together to form a 4-7 membered ring, optionally incorporating an additional N, O, S atom; wherein the 4-7 membered ring is optionally substituted with C1-C4 alkyl, halogen, OH, CN, halogen, or N(R4)2; R6 is H or alkyl; R7 is H, alkyl, optionally substituted acyl, alkyl-O-acyl, substituted or unsubstituted aminoacyl, carbamoyl, carbamido, alkyl sulfonyl, aryl sulfonyl, heteroaryl sulfonyl, 4-7 membered heterocycle sulfonyl, or C4-C7 cycloalkyl-acyl; and p is 1 or 2; or a pharmaceutically acceptable salt, hydrate, solvate, or tautomer thereof. |
