Compositions and methods comprising binding proteins for adalimumab

摘要

Compositions and methods comprising proteins that bind specifically to adalimumab are disclosed herein. Adalimumab is a monoclonal antibody specific for the cytokine TNF-α and was developed to treat TNF-α mediated inflammatory diseases. In one aspect of the instant invention, the binding proteins are antibodies directed toward adalimumab. These antibodies, including binding fragments thereof, can be used in a clinical setting as well as for research and development. For example, these anti-adalimumab antibodies can be employed to neutralize adalimumab.

主权项

1. An isolated monoclonal antibody, or an antigen binding portion thereof, which specifically binds adalimumab and comprises the amino acid sequences of all the complementarity determining regions (CDRs) of antibody 5A1-2A8, produced by a hybridoma having ATCC accession number PTA-8513.