Radiofrequency hyperthermia device with target feedback signal modulation

摘要

The present invention relates to a radiofrequency (RF) hyperthermia device for capacitive coupling comprising a radiofrequency source, an amplifier, a sensor, a feedback amplifier and a modulation signal generator, wherein the radiofrequency source produces a source signal which is modulated by the modulation signal generator, amplified by the amplifier and directed to a target, the sensor receives a feed back signal from the target that is directed to the feed back amplifier, wherein the feedback signal is amplified by the feedback amplifier and modulates the source signal to generate a target modified signal. This radiofrequency (RF) hyperthermia device is designed for increasing the selectivity of the hyperthermia treatment.

主权项

1. A radiofrequency hyperthermia device for capacitive coupling, without a dipole antenna, comprising:
a radiofrequency source; an amplifier; a sensor configured for detecting a reflected or transmitted power signal from a target tissue; a pink noise generator; a modulator which effects changes in amplitude of an output of the radiofrequency source based on an output of the pink noise generator; at least one electrode; and at least one counter-electrode; wherein the radiofrequency source is configured to produce a carrier wave having a carrier frequency, the pink noise generator is configured to produce an information signal, and the modulator is configured to modulate the amplitude of the carrier wave based on the information signal produced by the pink noise generator through amplitude modulation to generate a modulated carrier wave signal; wherein the amplifier is configured to amplify the modulated carrier wave signal and to direct the modulated carrier wave signal to the target tissue through the at least one electrode and at least one counter-electrode; wherein the sensor is configured to receive a feedback signal from the target tissue, and the feedback signal is configured to provide feedback correction to the information signal provided by the pink noise generator through a multiplicator to generate a target modified modulated signal; and wherein the radiofrequency hyperthermia device is configured to generate an electric field between the electrode and the counter-electrode and use capacitive coupling to apply a RF current through the target tissue.