| 发明名称 |
T Cell Regulation |
| 摘要 |
Combinations of anti-cancer antibodies and inhibitory antibodies to CD223 overcome immune suppression in cancer patients. The inhibitory antibodies may be generated in an animal by injection of fragments of CD223. Antibodies may be monoclonal antibodies or single chain antibodies or humanized antibodies. |
| 申请公布号 |
US2016108121(A1) |
申请公布日期 |
2016.04.21 |
| 申请号 |
US201514973806 |
申请日期 |
2015.12.18 |
| 申请人 |
St. Jude's Children's Research Hospital Inc. ;The Johns Hopkins University |
发明人 |
Pardoll Drew M.;Huang Ching-Tai;Powell Jonathan;Drake Charles;Vignali Dario A.;Workman Creg J. |
| 分类号 |
C07K16/28;C07K16/18 |
主分类号 |
C07K16/28 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for treating a mammal with a cancer, comprising:
administering to the mammal a first antibody which specifically binds to CD223 protein and inhibits negative T cell regulatory function of CD223; and administering to the mammal a second antibody which is an anti-cancer antibody. |
| 地址 |
Memphis TN US |
