Abuse Deterrent Immediate Release Formulation

摘要

The present invention relates to an immediate release orally administrable abuse-deterrent pharmaceutical formulation comprising: at least one pharmaceutically active ingredient susceptible to abuse; at least one gelling polymeric compound selected from the group consisting of: polysaccharides, sugars, sugar derived alcohols, starches, starch derivatives, cellulose derivatives, Carrageenan, pectin, sodium alginate, gellan gum, xanthan gum, poloxamer, Carbopol®, PolyOx®, povidone, hydroxypropyl methylcellulose (HPMC), hypermellose, and combinations thereof; at least one disintegrant and optionally at least one surfactant, wherein said formulation exhibit properties related to deterring the abuse, via injection or nasal inhalation when being tampered and exposed to aqueous, alcoholic, acidic and basic media.

主权项

1. An immediate release orally administrable abuse-deterrent pharmaceutical formulation comprising:
a) at least one pharmaceutically active ingredient susceptible to abuse within a matrix; b) at least one gelling polymeric compound, selected from a group consisting of: a natural resin, a natural gum, a polymer and a combination thereof; c) at least one disintegrant; and d) optionally a surfactant.