发明名称 |
CYTOTOXIC BENZODIAZEPINE DERIVATIVES |
摘要 |
The invention relates to novel benzodiazepine derivatives with antiproliferative activity and more specifically to novel benzodiazepine compounds of formula (I)-(VII). The invention also provides conjugates of the benzodiazepine compounds linked to a cell-binding agent. The invention further provides compositions and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the compounds or conjugates of the invention. |
申请公布号 |
US2016108129(A1) |
申请公布日期 |
2016.04.21 |
申请号 |
US201514849270 |
申请日期 |
2015.09.09 |
申请人 |
IMMUNOGEN, INC. |
发明人 |
Li Wei;Miller Michael Louis;Fishkin Nathan Elliott;Chari Ravi V.J. |
分类号 |
C07K16/30;A61K47/48;A61K31/5517 |
主分类号 |
C07K16/30 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
WALTHAM MA US |