| 发明名称 |
PROCESS FOR THE STEREOSELECTIVE PREPARATION OF A PYRAZOLE-CARBOXAMIDE |
| 摘要 |
The present invention relates to a process for the enantioselective preparation of the compound of formula (Ib), which process comprises a) reducing the (E)- or (Z)-form of a compound of formula (II), with an enantioselective reagent to a compound of formula (IIIa), and b) acylating the compound of formula (IIIa) with the compound of formula (IV), or c) coupling the compound of formula (IV) with the compound of formula (II), to give a compound of formula (V) and d) reducing compound of formula (V) in the presence of hydrogen, a catalyst and a chiral ligand, to the compound of formula (Ib).; |
| 申请公布号 |
US2016108001(A1) |
申请公布日期 |
2016.04.21 |
| 申请号 |
US201414892386 |
申请日期 |
2014.06.19 |
| 申请人 |
SYNGENTA PARTICIPATIONS AG |
发明人 |
DUMEUNIER Raphael;KESSABI Jilali;WENDEBORN Sebastian Volker;NUSSBAUMER Hannes |
| 分类号 |
C07D231/14;C07C239/20 |
主分类号 |
C07D231/14 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A process for the enantioselective preparation of the compound of formula (Ib) which process comprises a) reducing the (E)- or (Z)-form of a compound of formula (II) with an enantioselective reagent to give a compound of formula (IIIa) and b) acylating the compound of formula (IIIa) with the compound of formula (IV)or
c) coupling the compound of formula (IV) with the compound of formula (II), to give a compound of formula (V) and d) reducing the compound of formula (V) in the presence of hydrogen, a catalyst and a chiral ligand, to give the compound of formula (Ib). |
| 地址 |
Basel CH |
