Analytical aids with hydrophilic coating containing nanoparticles with silica structure and methods of producing and using the same

摘要

Disclosed herein are analytical aids having a surface coated at least partially with a hydrophilic coating, where the hydrophilic coating includes nanoparticles with silica structure and an average particle size in a range from about 1 nm to about 500 nm. Also disclosed are methods of producing the analytical aids, as well as using the analytical aids in, for example, a sampling device containing the at least partially coated analytical aid.

主权项

1. An analytical aid comprising:
a surface coated at least partially with a hydrophilic coating, wherein the hydrophilic coating contains nanoparticles with silica structure and an average particle size in a range from about 1 nm to about 500 nm, wherein the nanoparticles comprise groups of structure (I) or (II): wherein in each of the groups of structure (I), independently of one another, R is selected from the group consisting of H, a metal-containing ion, wherein Rw, Rx, Ry and Rz, independently of one another, are selected from H and alkyl, wherein Ra, Rb and Rc, independently of one another, are optionally substituted residues, selected from the group consisting of H, alkyl, aryl, heteroaryl, cycloalkyl, cycloheteroalkyl, alkenyl and alkoxyalkyl, wherein n, m and p, independently of one another, are 0 or 1, and wherein M+ is a metal ion and A− is a physiologically compatible anion.