| 发明名称 |
ER-stress inducing compounds and methods of use thereof |
| 摘要 |
The invention relates to methods for identifying ER-stress inducing compounds that target cancer stem cells. In some aspects, the invention relates to treatment methods that use ER-stress inducing compounds that specifically target cancer stem cells for inhibiting the growth and/or survival of cancer stem cells in a subject in need thereof. Other aspects of the invention relate to the use of cancer stem cell biomarkers in the selection of a treatment for inhibiting the growth and/or survival of cancer stem cells in a subject in need thereof. |
| 申请公布号 |
US9316631(B1) |
申请公布日期 |
2016.04.19 |
| 申请号 |
US201314057473 |
申请日期 |
2013.10.18 |
| 申请人 |
|
发明人 |
Gupta Piyush;Feng Yuxiong |
| 分类号 |
A61K31/415;A61K31/35;A61K31/41;G01N33/50;G01N33/574;A61K31/4025;A61K31/40 |
主分类号 |
A61K31/415 |
| 代理机构 |
Wolf, Greenfield & Sacks, P.C. |
代理人 |
Wolf, Greenfield & Sacks, P.C. |
| 主权项 |
1. A method of selecting a treatment for a subject having a carcinoma, the method comprising:
conducting an assay to determine the extent of UPR signaling in cells of the carcinoma, wherein, if the extent of UPR signaling in the cells of the carcinoma is higher than the extent of UPR signaling in cells from normal epithelium, then an ER-stress inducing compound is suitable for treating the subject, and if the extent of UPR signaling in the cells of the carcinoma is equal to or less than the extent of UPR signaling in cells from normal epithelium, then an ER-stress inducing compound is not suitable for treating the subject; and selecting a treatment for the subject based at least in part on the results of the assay. |
| 地址 |
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