SPIRODIAMINE DERIVATIVES AS ALDOSTERONE SYNTHASE INHIBITORS
摘要
The invention provides compounds having the general formula (I) pharmaceutical compositions containing the compounds and a process for their preparation. The compounds act as aldosterone synthase inhibitors and are for use in the treatment or prevention of chronic kidney disease, congestive heart failure, hypertension, primary aldosteronism and Cushing syndrom.
申请公布号
WO2016055394(A1)
申请公布日期
2016.04.14
申请号
WO2015EP72887
申请日期
2015.10.05
申请人
F. HOFFMANN-LA ROCHE AG;HOFFMANN-LA ROCHE INC.
发明人
AEBI, JOHANNES;AMREIN, KURT E.;CHEN, JUNLI;HORNSPERGER, BENOIT;KUHN, BERND;LIU, YONGFU;LI, DONGBO;MAERKI, HANS PETER;MARTIN, RAINER E.;MAYWEG, ALEXANDER;TAN, XUEFEI;WU, JUN;YU, JIANHUA