| 发明名称 |
USE OF A TRUNCATED CCN1 PROMOTER FOR CANCER DIAGNOSTICS, THERAPEUTICS AND THERANOSTICS |
| 摘要 |
Recombinant vectors in which expression of one or more elements (e.g. genes required for viral replication, detectable imaging agents, therapeutic agents, etc.) is driven by a truncated CCN 1 cancer selective promoter (tCCN1-Prom) are provided, as are cells and transgenic animals that contain such vectors. The vectors are used in cancer therapy and/or diagnostics, and the transgenic mice are used to monitor cancer progression, e.g. in screening assays. |
| 申请公布号 |
US2016101193(A1) |
申请公布日期 |
2016.04.14 |
| 申请号 |
US201414895247 |
申请日期 |
2014.06.04 |
| 申请人 |
VIRGINIA COMMONWEALTH UNIVERSITY |
发明人 |
Fisher Paul B.;Das Swadesh K.;Dash Rupesh;Sarkar Devanand;Sarkar Siddik;Windle Jolene |
| 分类号 |
A61K48/00;A61K49/00;C12N15/86 |
主分类号 |
A61K48/00 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A cancer cell comprising a recombinant truncated CCN1 cancer selective promoter having a nucleotide sequence as set forth in SEQ ID NO: 1. |
| 地址 |
Richmond VA US |
