METHOD AND SYSTEM FOR SENSITIVITY ANALYSIS IN MODELING BLOOD FLOW CHARACTERISTICS

摘要

Embodiments include systems and methods for determining cardiovascular information for a patient. A method includes receiving patient-specific data regarding a geometry of the patient's vasculature; creating an anatomic model representing at least a portion of the patient's vasculature based on the patient-specific data; and creating a computational model of a blood flow characteristic based on the anatomic model. The method also includes identifying one or more of an uncertain parameter, an uncertain clinical variable, and an uncertain geometry; modifying a probability model based on one or more of the identified uncertain parameter, uncertain clinical variable, or uncertain geometry; determining a blood flow characteristic within the patient's vasculature based on the anatomic model and the computational model of the blood flow characteristic of the patient's vasculature; and calculating, based on the probability model and the determined blood flow characteristic, a sensitivity of the determined fractional flow reserve to one or more of the identified uncertain parameter, uncertain clinical variable, or uncertain geometry.

主权项

1. A system for determining cardiovascular information for a patient, the system comprising:
at least one computer system configured to:
create a computational model of a first blood flow characteristic based on an anatomic model, the anatomical model representing at least a portion of the patient's vasculature and being based on based on patient-specific data regarding a geometry of at least the portion of the patient's vasculature;modify a probability model based on one or more of an uncertain parameter, uncertain clinical variable, or uncertain geometry;determine a range of a second blood flow characteristic within the patient's vasculature based on a confidence interval and the computational model of the first blood flow characteristic of the patient's vasculature; andcalculate, based on the probability model and the determined range of the second blood flow characteristic, a sensitivity of the determined range of the second blood flow characteristic to one or more of the identified uncertain parameter, uncertain clinical variable, or uncertain geometry.