TREATMENT AND PREVENTION OF CARDIOVASCULAR DISEASE AND THROMBOSIS

摘要

Provided herein are compositions for the treatment and/or prevention of cardiovascular disease (CVD), and methods of application and use thereof. In particular, the present invention provides treatment and/or prevention of cardiovascular disease with compounds that inhibit the production of TMA in the gut, such as 3,3-dimethyl-1-butanol (DMB) or other compounds represented by Formula I or as shown in FIGS. 20-23.

主权项

1. A method for the treatment and/or prevention of cardiovascular disease and/or thrombosis comprising:
a) identifying a subject as having increased platelet aggregation and/or elevated TMAO levels, and b) administering to said subject: i) a composition comprising a compound selected from the group consisting of: N,N-dimethylethanolamine (DMEA), N-methylethanolamine (MEA), ethanolamine (EA), trimethylsilyl ethanol, and P,P,P-trimethyl ethanolphosphine; and/or ii) a composition comprising a compound represented by Formula I: wherein n is an integer, or n is 0, indicating that CH2 is not present; wherein Y is C, Si, P, S, Ge, Sn, Pb, P, As, Sb, or Bi; wherein X is O or S and the corresponding bond is either present or absent or double, wherein R is H, an alkyl group, alkenyl group, alkynyl group, phenyl group, or a benzyl group; wherein Z is C, CH2, CH, O or S, wherein XR is an ester, thioester, or thionester; glycerol, or one of the following three formulas: wherein R′ is H, an alkyl group, alkenyl group, alkynyl group, phenyl group, or a benzyl group; and wherein X′ is O, or S.