COMBINATION THERAPY FOR TREATING PROTEIN DEFICIENCY DISORDERS

摘要

PROBLEM TO BE SOLVED: To provide methods for improving the biological efficiency and cost efficiency of a protein replacement therapy in the treatment and the like of protein deficiency or other disorders requiring the administration of replacement proteins.SOLUTION: The invention provides methods for increasing in vitro stability of purified recombinant human wild type α-galactosidase, for parenteral administration to a human, in the formulation having a pH higher than 5.0. The α-galactosidase in a pharmaceutically acceptable carrier is brought into contact with 1-deoxygalactonojirimycin in an amount effective to increase the in vitro stability of the purified α-galactosidase.SELECTED DRAWING: None