| 主权项 |
1. A dosage form having reduced abuse potential comprising:
(a) a first population of granules, beads or minitablets comprising a psychoactive drug, and (b) a second population of drug-free granules, beads or minitablets comprising:
(i) a core comprising at least one deterrent substance selected from the group consisting of activated charcoal and alumina and(ii) a coating surrounding the core, wherein said coating does not dissolve in the gastrointestinal tract and comprises a polymer selected from the group consisting of cellulose acetate, cellulose acetate butyrate, cellulose acetate propionate, ethyl cellulose, poly(ethyl acrylate), poly(methyl methacrylate), and poly(trimethylammonioethylmethacrylate chloride),which is further coated with an alkaline soluble coating comprising a polymer selected from the group consisting of cellulose acetate phthalate, cellulose acetate trimellitate, hydroxypropyl methyl cellulose phthalate, polyvinyl acetate phthalate, carboxymethylethylcellulose, and co-polymerized methacrylic acid/methacrylic acid methyl esters, and wherein the deterrent substance does not interact with the drug when properly administered. |
