Synthetic serous membranes and methods for making the same

摘要

The present disclosure relates to casting-mold imprints and synthetic reproductions of serous membranes for tissue engineering and organogenesis. The imprints and synthetic membranes disclosed herein may be composed of distinct biocompatible polymers, which provide a mechanism for separation. Further disclosed herein are methods for making imprints and synthetic membranes that mimic natural scrous membranes.

主权项

1. A synthetic serous membrane comprising one or more biocompatible polymers that form a topological duplicate at the nano- or micro-scale level, of a donor serous membrane, wherein the topological duplicate is a synthetic pericardial, pleural, or peritoneal membrane, or any combination thereof, wherein the synthetic pericardial, pleural, or peritoneal membrane includes a two-layer membrane, wherein the synthetic serous membrane is free from the donor serous membrane and is formed without collagen.