发明名称 Non-invasive monitoring of blood metabolite levels
摘要 Solutions for non-invasively monitoring blood metabolite levels of a patient are disclosed. In one embodiment, the method includes: repeatedly measuring a plurality of electromagnetic impedance readings with a sensor array from: an epidermis layer of a patient and one of a dermis layer or a subcutaneous layer of the patient, until a difference between the readings exceeds a threshold; calculating an impedance value representing the difference using an equivalent circuit model and individual adjustment factor data representative of a physiological characteristic of the patient; and determining a blood metabolite level of the patient from the impedance value and a blood metabolite level algorithm, the blood metabolite level algorithm including blood metabolite level data versus electromagnetic impedance data value correspondence of the patient.
申请公布号 US9307935(B2) 申请公布日期 2016.04.12
申请号 US201013377162 申请日期 2010.06.04
申请人 BioSensors, Inc. 发明人 Pluta Sarah E.;Hewitt John W.
分类号 A61B5/1468;A61B5/145;A61B5/053;A61B5/1495 主分类号 A61B5/1468
代理机构 Hoffman Warnick LLC 代理人 Hoffman Warnick LLC
主权项 1. A method of determining a blood metabolite level of a patient, the method comprising: repeatedly transmitting, using a sensor array, a plurality of electromagnetic signals into an epidermis layer of a patient and one of a dermis layer of the patient, or the dermis layer and a subcutaneous layer of the patient; repeatedly obtaining a plurality of return electromagnetic impedance readings, using the sensor array, from: the epidermis layer of a patient and the one of the dermis layer or the dermis layer and the subcutaneous layer of the patient, until a difference between the transmitted electromagnetic signals and the return electromagnetic impedance readings exceeds a threshold, the threshold being equal to approximately a ten percent difference, wherein exceeding the threshold indicates that the transmitted plurality of electromagnetic signals penetrated the at least one of the dermis layer, or the dermis layer and subcutaneous layer, wherein the repeatedly transmitting of the plurality of electromagnetic signals and the repeatedly obtaining of the plurality of return electromagnetic impedance readings is performed within approximately ten minutes; calculating, at a glucose monitoring system having a processing unit and a memory, an impedance value representing the difference between the transmitted electromagnetic signals and the return electromagnetic signals using an equivalent circuit model and individual adjustment factor data representative of a physiological characteristic of the patient; and determining a blood metabolite level of the patient from the impedance value and a blood metabolite level algorithm, the blood metabolite level algorithm including blood metabolite level data versus electromagnetic impedance data value correspondence.
地址 Schenectady NY US