发明名称 |
PYRAZOLQUINOLINDERIVAT SOM PDE9-INHIBITORER |
摘要 |
A compound or pharmacologically acceptable salt thereof represented by the formula (I) has PDE9 inhibitory action, so that the intracerebral cGMP concentration is anticipated to be elevated. The PDE9 inhibitory action and the increase in cGMP lead to the improvement of learning and memory behaviors, and the compound (I) has a potential use of a therapeutic agent for cognitive dysfunctions in Alzheimer's disease.
wherein R 1 is a hydrogen atom; R 2 is an aromatic ring group, etc.; R 3 is a hydrogen atom, etc; R 4 is a hydrogen atom; R 5 is an oxepanyl group, etc.; R 6 is a hydrogen atom. |
申请公布号 |
DK2769980(T3) |
申请公布日期 |
2016.04.11 |
申请号 |
DK20120837953T |
申请日期 |
2012.10.04 |
申请人 |
EISAI R&D MANAGEMENT CO., LTD. |
发明人 |
NORIMINE, YOSHIHIKO;TAKEDA, KUNITOSHI;HAGIWARA, KOJI;SUZUKI, YUICHI;ISHIHARA, YUKI;SATO, NOBUAKI |
分类号 |
C07D471/04;A61K31/437;A61K31/444;A61K31/506;A61P25/28;A61P43/00 |
主分类号 |
C07D471/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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