| 摘要 |
The invention discloses a preparation method of cajanin and substances with a similar structure. According to the invention, acyl acetate and diketene are subject to a condensation reaction, such that an intermediate compound II is obtained; the intermediate compound II is subject to an alkylation reaction and a halogenation reaction, such that an intermediate compound IV is obtained; the intermediate compound IV is subject to a condensation reaction with an organic phosphine reagent, and is subject to a witting reaction, such that a compound VI is obtained; the compound VI is subject to a dehydrocarbylation and pentanol iosprene conversion reaction, and the reactant is hydrolyzed or alcoholyzed, such that cajanin I and substances with the similar structure are obtained. According to the invention, cajanin and substances with the similar structure are prepared through a chemical synthetic method. The technical process adopted by the synthetic route is easy to operate, the yield is good, and the product purity is high. The method provided by the invention assists in providing a basis for further researches, developments and applications of various pharmacologic actions of cajanin. |
