发明名称 |
PHARMACEUTICAL COMPOSITION OF ANTIBIOTICS AND PREBIOTICS FOR PREVENTING AND TREATING DYSBIOSIS DURING ANTIBACTERIAL THERAPY |
摘要 |
The invention relates to medicine and pharmacology, in particular to pharmaceutical compositions containing the following antimicrobial preparations: antibiotics and sulphanylamides combined with prebiotic in the form of a lactulose. The composition is used for preventing enteral dysbiosis arising during antibiotic therapy using the wide range of preparations. The inventive phamaceutical composition contains antibiotic or a sulphanylamide preparation and lactulose, wherein the antibiotic particle size ranges form 20 to 160 mkm, the sulphanylamide preparation particle size ranges from 40 to 150 mkm and the lactulose has a particle size equal to or less than 0.3 mm and the purity of at least 97 %, with the ratio of the antibiotic and lactulose ranging from 1:0.1 to 1:100, and the ratio of the sulphanylamide preparation and lactulose of 1:12, said composition being internally administered. The inventive preparations contribute to the preservation of antibiotic-damaged intestinal flora by producing selective prebiotic action on the growth of dominant types of microflora of the large intestine,such as lactobacilli and bifidobacteria. |
申请公布号 |
HRP20151402(T1) |
申请公布日期 |
2016.04.08 |
申请号 |
HR2015P001402T |
申请日期 |
2015.12.21 |
申请人 |
Dikovskiy, Aleksander Vladimirovich |
发明人 |
Dorozhko, Oleg Valentinovich;Rudoi, Boris Anatolievich |
分类号 |
A61K47/26;A61K31/7016;A61K45/06;A61P1/00 |
主分类号 |
A61K47/26 |
代理机构 |
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