MRG RECEPTOR MODULATORS

摘要

The present invention is in the field of molecular biology, more particularly, the present invention relates to drug screening, assay development and identification and use of modulators for G-protein coupled receptor/ligand pair MRGX2/CXCL14 within drug discovery.

主权项

1. A method of screening for an antagonist of a Mrg receptor comprising the steps of
a. contacting a test compound with a Mrg receptor polypeptide in the presence of a CXCL14 polypeptide, b. detecting binding of a CXCL14 polypeptide to said Mrg receptor polypeptide in the presence of said test compound, c. contacting CXCL14 with a Mrg receptor polypeptide in the absence of said test compound, and d. detecting binding of a CXCL14 polypeptide to said Mrg receptor polypeptide in the absence of said test compound.